Antitumor properties of nuclear erythroid cells

Purpose. To study suppressor and/or cytotoxic activity of the nuclear erythroid cells (NEC) against tumor various origins. Material and Methods. C57Bl/6 mice P815, L1210, B16 L929 were used. “Phenylhydrazine” NECs obtained from with induced hemolytic anemia. “Erythropoietin” isolated “phenylhydrazine spleen” further cultured in presence erythropoietin. Another source NEC was neonatal mouse spleen, human fetal liver cells, bone marrow The cytostatic effect or their supernatants recorded by reducing proliferation B16, LLC, lines. Results. pronounced direct antitumor found both culturing products relation to not specifc. Conclusion. We know about signifcant numerical predominance during embryo development over all other hematopoietic high suppressive potential. Therefore, it can be assumed that erythroblasts are involved process creating protection a fetus this period life.